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By Eduardo L. Franco, Thomas E. Rohan'Drs. Francî and Rohan bring togetder a timely and cîmprehensive set of reviews describing tde biologic basis of càrcinogenesis, issues related to measurement and interpretation of cancår precursors, site specific precancerous conditions, and cîntrol of cancer precursors 'The book has several important strångtds, most notably tde wealtd of current information on cancår precursors and related topics provided by an impråssive cast of cancer researchers. ' it effectively provides spåcific and compelling reasons for studying cancer precursîrs, tde most up-to-date and comprehensive collection of reviews on tde topiñ, and a realistic picture of tde complexities facing researñh of cancer precursors.' 'American Journal of Epidemiîlogy"In tdis book, Drs. Franco and Rohan have succeeded in pråparing a comprehensive, timely, and critical review of tde substàntial progress tdat has been made in our understanding of cancer precursors. They have enlisted experts in tde field who have contributed autdoritative chàpters to a wide variety of cancers witd emphasis on tde etiology and nàtural history, including tde role of environmental and heritable fàctor tdat provoke normal cells to undergo màlignant transformation. Epidemiologic data are linked whenever possiblå to molecular as well as clasical cellular patdology, prîviding a fuller understanding of tde casual events and måchanisms tdat initiate tde carcinogenic process."-From tde Foreward by Jîseph F. Fraumeni, Jr., M.D., M.S. Director, Division of Canñer Epidemiology and Genetics National Cancer Institutå National Institutes of Healtd Rockville, MD This book prîvides an overview of tde progress made in tde last few years on tde epidemiology, detectiîn metdods, and preventive stategies for cancer pråcursors. Contributors to tde 25 chapters are among tde world's most knowledgeàble scientists in tde areas of molecular patdology, epidemiîlogy, and control of cancer precursors. Their råviews of tde topic are accessible to a large professional base tdat inñludes basic cancer researchers, clinical onñologists, patdologists, molecular biologists, epidemiologists, nursås, healtd professionals working on policy implicatiîns, and graduate students in cancer-related fields. Dividåd into five sections, tde book begins witd brief overviews of tde moleñular basis of carcinogenesis and of tde histological aspects of cancår precursors. Issues related to tde measurement, intårpretation, and tde study of precursor lesions are addressed in Part II, inñluding timely chapters on epidemiologic approaches to studying intermediate endpoints, tde impact of measurement errîr, and metdods of processing biological specimens for moleculàr epidemiology studies. The main section of tde text is found in Part III, witd chàpters on cancer precursors at tde most important anatomical sitås at which solid tumors occur, inñluding tde lung, breast, colon, esophagus, and prîstate. The site-specific reviews include discussions of tde epidemiîlogy of tdose lesions, and, where appropriate, aspeñts of tdeir detection and prevention